BioNano Genomics. has been granted a patent for a fluidic system designed for processing and extracting nucleic acids from various samples, including tissues and cells. The patented kit features a microfluidic chip with multiple fluidic channels and reservoirs for efficient sample processing and buffer management. GlobalData’s report on BioNano Genomics gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on BioNano Genomics, Microfluidic devices was a key innovation area identified from patents. BioNano Genomics's grant share as of June 2024 was 33%. Grant share is based on the ratio of number of grants to total number of patents.

Microfluidic systems for nucleic acid extraction and processing

Source: United States Patent and Trademark Office (USPTO). Credit: BioNano Genomics Inc

The granted patent US12006496B2 describes a specialized kit designed for fluidic analysis, featuring a microfluidic chip with multiple fluidic channels. Each channel is interconnected with various reservoirs, including a sample reservoir, three buffer reservoirs, and an elution reservoir. The kit is versatile, allowing for the inclusion of different types of buffers such as leading electrolyte, trailing electrolyte, sample, and lysis buffers. Additionally, the kit can incorporate enzymes like RNase, DNase, and proteinase, enhancing its functionality for biochemical applications. The design includes branched fluidic channels that facilitate isotachophoresis (ITP), with specific sections for loading samples and eluting results.

The microfluidic chip's architecture is further detailed, with provisions for capillary barriers and gas channels to optimize fluid movement and pressure control. Each fluidic channel is equipped with a loading section that connects to a trailing electrolyte well and a sample input well, ensuring efficient sample processing. The ITP section is designed to include a leading electrolyte branch and an elution branch, each with dedicated wells for buffering and elution. The patent outlines configurations for up to eight fluidic channels, emphasizing the kit's potential for high-throughput applications in molecular biology and related fields.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.