Pacific Biosciences of California. has been granted a patent for an integrated device designed to analyze fluorescent species. The device features an array of reaction cells with nanoscale apertures, illumination waveguides, optical filters, and detector elements, enabling precise measurement of optical signals from multiple sources. GlobalData’s report on Pacific Biosciences of California gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Pacific Biosciences of California, Optoelectronic biosensors was a key innovation area identified from patents. Pacific Biosciences of California's grant share as of July 2024 was 55%. Grant share is based on the ratio of number of grants to total number of patents.
Integrated device for analyzing fluorescent signals from reaction cells
The patent US12071664B2 describes an integrated device designed for the analysis of fluorescent species, featuring a sophisticated arrangement of components that enhance the detection and analysis of fluorescent signals. Central to the device is an array of reaction cells equipped with nanoscale apertures, which are illuminated from below by at least one illumination waveguide. This setup allows fluorescent species within the reaction cells to emit light, which is then selectively filtered by an array of optical filter elements positioned beneath the illumination waveguide. Each reaction cell is paired with two filter elements, each designed to pass light from different wavelength ranges while rejecting the other, facilitating the detection of multiple fluorescent signals. The emitted light is directed to an array of detector elements, where single pixel detectors are employed to capture the signals without the interference of air or free space.
Additionally, the device may include optical elements such as lenses and mirrors to further direct the fluorescent light to the detectors. The design incorporates nanoscale wells and optical confinement structures, which can include zero mode waveguides, enhancing the sensitivity and specificity of the analysis. The fluorescent species can consist of distinctly labeled nucleotides, and the device is capable of performing various functions, including single molecule real-time DNA sequencing, monitoring nucleotide incorporation kinetics, and detecting binding or hybridization reactions. Furthermore, the device is equipped with a fluidic conduit for reagent delivery, making it versatile for applications such as antibody assays and other biochemical analyses.
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