Oxford Nanopore Technologies has been granted a patent for an apparatus that controls the insertion of membrane channels into a membrane. The system utilizes two baths, electrodes, and a voltage reduction unit to manage the potential difference across the membrane, thereby regulating further channel insertions. GlobalData’s report on Oxford Nanopore Technologies gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Oxford Nanopore Technologies, Prognostic biomarkers was a key innovation area identified from patents. Oxford Nanopore Technologies's grant share as of July 2024 was 31%. Grant share is based on the ratio of number of grants to total number of patents.

Apparatus for controlling membrane channel insertion into membranes

Source: United States Patent and Trademark Office (USPTO). Credit: Oxford Nanopore Technologies Plc

The patent US12042790B2 describes an innovative apparatus and method for controlling the insertion of membrane channels into a membrane. The apparatus consists of two baths containing different liquids, with a membrane separating them. It features electrodes that apply a potential difference across the membrane to facilitate the insertion of membrane channels. A key component is the membrane voltage reduction unit, which is connected in series with the membrane. This unit adjusts the potential difference across the membrane in response to changes in resistance caused by channel insertion, effectively preventing further channel insertion when necessary. The design allows for the driving voltage to be increased rapidly, ensuring efficient control over the insertion process.

Additionally, the patent outlines various configurations for the membrane voltage reduction unit, including options with resistive components and diodes, which help maintain the appropriate potential difference for channel insertion while limiting excessive insertion. The method described allows for the application of a driving voltage that can be progressively increased, with the potential for simultaneous operation across multiple membranes or portions thereof. The apparatus is particularly noted for its ability to function without the need for complex logic control, making it a versatile tool for applications involving amphiphilic membranes. Overall, this patent presents a significant advancement in membrane technology, with potential implications for various fields, including biotechnology and materials science.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.