3-D Matrix has been granted a patent for a method that deaerates and sterilizes self-assembling peptide solutions. The process involves two deaerating steps: the first by lowering pressure and filtering, and the second through vibration and further pressure reduction. GlobalData’s report on 3-D Matrix gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on 3-D Matrix, Cyclosporin derivatives was a key innovation area identified from patents. 3-D Matrix's grant share as of June 2024 was 32%. Grant share is based on the ratio of number of grants to total number of patents.
The granted patent US12006085B2 outlines a method for deaerating and sterilizing a self-assembling peptide solution that contains at least 0.5 weight % of a self-assembling peptide. The process involves a two-step deaeration procedure, beginning with a vacuum deaeration of the peptide solution, followed by filtration through a sterilizing filter to produce a peptide filtrate. The second deaeration step utilizes vibration at a frequency between 20 and 360 revolutions per minute, combined with a pressure reduction of at least 0.05 MPa. The sterilizing filter is specified to have an average pore size of less than 0.22 µm and can be made from various materials, including polyethersulfone.
Additional claims detail specific parameters for the deaeration steps, such as the rate of pressure reduction and the duration of the first deaeration step, which should last at least 30 minutes. The method also allows for the use of sterilizing agents like ethylene oxide gas or hydrogen peroxide gas. The patent further describes the construction and preparation of the sterilizing filter, including washing procedures prior to integrity testing. Notably, the filtering process can be enhanced by using two filters operating in parallel, ensuring effective sterilization and deaeration of the self-assembling peptide solution.
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