Carl Zeiss has been granted a patent for a method to detect emission light in a laser scanning microscope. The method involves spatially oversampling the detection point spread function using a matrix sensor, spectrally separating the emission light, and reversing the spectral separation for some pixels to evaluate intensities. GlobalData’s report on Carl Zeiss gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Carl Zeiss, was a key innovation area identified from patents. Carl Zeiss's grant share as of February 2024 was 46%. Grant share is based on the ratio of number of grants to total number of patents.
Spectral detection of emission light in laser scanning microscope
A recently granted patent (Publication Number: US11921274B2) discloses a method and apparatus for detecting emission light in a laser scanning microscope. The method involves detecting a detection point spread function by spatially oversampling it using a two-dimensional matrix sensor, spectrally separating the emission light, separately detecting the spectrally separated light, and evaluating intensities measured by the pixels. The evaluation process includes reversing the spectral separation for some pixels by assigning intensity values to a location in the image plane based on a displacement vector and wavelength associated with that location. The patent also covers identifying pixel regions assigned to emission of a dye based on measured spectra, determining spectral intensity distributions, spectral unmixing, and time-resolved measurements for fluorescence lifetimes.
The detection apparatus described in the patent includes a two-dimensional matrix sensor, an imaging optical unit, a dispersion device for spectral separation, and evaluation electronics for analyzing pixel intensities. The apparatus is configured to reverse spectral separation for some pixels by combining intensity values based on spectral and spatial intensity distributions. Additional features include a main color splitter, control and evaluation unit for data analysis, and the ability to determine fluorescence lifetimes of dyes. The patent also details the use of microlenses to increase detection efficiency, limitations on spectral bandwidth per pixel, and the use of a zoom system in the imaging optical unit for enhanced performance. Overall, the patent provides a comprehensive solution for efficient and accurate detection of emission light in laser scanning microscopes, with applications in various fields requiring high-resolution imaging and spectral analysis.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
