CytoSorbents has patented a method using biocompatible polymer systems to adsorb toxins and inflammatory mediators from physiologic fluids. The polymer coating includes various compounds like polyol and zwitterionic functionality to reduce endotoxins in blood and blood products, preventing endotoxemia. GlobalData’s report on CytoSorbents gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on CytoSorbents, Wearable breast pumps was a key innovation area identified from patents. CytoSorbents's grant share as of January 2024 was 45%. Grant share is based on the ratio of number of grants to total number of patents.
Method of adsorbing toxins and inflammatory mediators using polymer system
A recently granted patent (Publication Number: US11826724B2) discloses a method for adsorbing toxins and inflammatory mediators from physiologic fluid using a polymer system. The polymer system, in the form of a solid support, is coated with various polymers such as poly(diethylaminoethyl methacrylate), poly(hydroxyethyl acrylate), and poly(N-vinylpyrrolidone), among others. The method involves contacting the physiologic fluid with the polymer system to remove toxins and inflammatory mediators with a molecular weight ranging from less than 0.5 kDa to 1,000 kDa.
Furthermore, the polymer system described in the patent is not only capable of adsorbing toxins and inflammatory mediators but also gram-negative and gram-positive bacteria, their fragments, and components. The polymer system can be in various forms such as beads, fibers, monolithic columns, films, membranes, or semi-permeable membranes. Additionally, the polymer system may contain pores with a specific range of sizes and volumes. The method outlined in the patent involves passing the physiologic fluid through an extracorporeal circuit containing a device with the polymer system, potentially improving the removal of toxins and inflammatory mediators efficiently. This innovative method could have significant implications in the field of medical treatments and therapies aimed at addressing conditions related to toxin accumulation and inflammation in the body.
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