Mesa Laboratories. has filed a patent for a method to detect multiple genetic variants in a sample. The process involves amplifying target nucleic acids, hybridizing them with oligonucleotides, extending the hybridized species, capturing them on a solid phase, and detecting them using mass spectrometry. This innovative approach allows for precise detection of genetic variants. GlobalData’s report on Mesa Laboratories gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Mesa Laboratories, was a key innovation area identified from patents. Mesa Laboratories's grant share as of January 2024 was 67%. Grant share is based on the ratio of number of grants to total number of patents.
Method for detecting multiple genetic variants using mass spectrometry
A recently filed patent (Publication Number: US20230407375A1) outlines a method for detecting the presence, absence, or amount of multiple genetic variants in a composition. The method involves preparing amplicons from target nucleic acid species, hybridizing these amplicons to oligonucleotide species, and contacting them with an extension composition containing terminating nucleotides. Importantly, the terminating nucleotides include a capture agent, and the extension process distinguishes between different genetic variants. The extended oligonucleotide species are then captured on a solid phase, released, and detected by mass spectrometry to determine the genetic variants' presence, absence, or quantity.
This innovative method offers a comprehensive approach to detecting genetic variants by utilizing a combination of hybridization, extension, and mass spectrometry techniques. By incorporating a capture agent into the terminating nucleotides and distinguishing between different variants based on their extension patterns, the method provides a reliable and efficient way to analyze genetic compositions. The use of mass spectrometry for detection adds a high level of sensitivity and accuracy to the process, ensuring precise results in determining the genetic variants' status. Overall, this patent presents a sophisticated and effective method for genetic variant detection that could have significant implications in various fields such as medical diagnostics, research, and personalized medicine.
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