Mesa Laboratories has been granted a patent for a method and product that can detect minor nucleic acid species in a sample containing a mixture of major and minor nucleic acid species. By skewing the concentrations of chain terminating reagents in favor of the minor nucleic acid species, the method improves the detection limit and allows for quantification of the minor nucleic acid species relative to the major nucleic acid species in the sample. GlobalData’s report on Mesa Laboratories gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData, Mesa Laboratories's grant share as of June 2023 was 1%. Grant share is based on the ratio of number of grants to total number of patents.
Method for detecting minor nucleic acid species in a sample
A recently granted patent (Publication Number: US11680289B2) describes a method for identifying the presence or absence of minor nucleic acid species in a sample. The method involves obtaining nucleic acids from a sample that includes a target nucleic acid, where the target nucleic acid has a major nucleic acid species and one or more minor nucleic acid species. The nucleic acids are then contacted with extension primers under specific conditions, generating chain terminated extension products corresponding to the minor nucleic acid species and/or the major nucleic acid species. The extension products are analyzed to identify the presence or absence of the minor nucleic acid species.
The patent also discloses a method for quantifying the amount of minor nucleic acid species in a nucleic acid sample. Similar to the previous method, nucleic acids are obtained from a sample containing a target nucleic acid with major and minor nucleic acid species. The nucleic acids are then contacted with extension primers under specific conditions, generating chain terminated extension products. The ratio of the amount of extension product corresponding to each minor nucleic acid species relative to the major nucleic acid species is determined. Based on this ratio and the known concentration of the chain terminating reagents, the amount of minor nucleic acid species relative to the major nucleic acid species is quantified.
The patent also provides variations of the methods, including the use of amplification primer pairs to obtain nucleic acids, the use of chain terminating reagents specific for each minor nucleic acid species, and the use of multiple reaction vessels or compartments for performing the method. Additionally, the patent describes the use of chain terminating nucleotides as reagents and the incorporation of mass labels for detection and quantification of the minor nucleic acid species.
Overall, this granted patent presents methods for identifying and quantifying minor nucleic acid species in a sample, which can be valuable in various fields such as genetic research, diagnostics, and personalized medicine.
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