Nexstim‘s patent involves a method for enhancing transcranial magnetic stimulation (TMS) treatment by combining anatomical and functional brain data in real-time. This system provides operators with a comprehensive view of brain networks affected by stimulation, improving diagnostic accuracy. GlobalData’s report on Nexstim gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Nexstim, was a key innovation area identified from patents. Nexstim's grant share as of May 2024 was 51%. Grant share is based on the ratio of number of grants to total number of patents.

Real-time brain network visualization for tms treatment

Source: United States Patent and Trademark Office (USPTO). Credit: Nexstim Plc

A recently granted patent (Publication Number: US11951324B2) outlines a method for enabling transcranial magnetic stimulation (TMS) treatment. The method involves acquiring an anatomical image and functional data of a subject's brain, coregistering these data to form a combined view, and aligning this view with a TMS stimulation device in real-time. The location for TMS pulse stimulation is selected based on this combined view, with the option to display functional data for the area of interest on the combined view.

Furthermore, the method includes utilizing various types of functional data such as PET, fMRI, rsfMRI, or DTI data, and applying a tractography algorithm in real-time to display white matter tracts. The selection of the stimulation location can be based on treating depression, excitability threshold, or specific brain structures like BA46 or BA9. The method also involves verifying the desired seed locations by stimulating terminal ends of white matter tracts and observing the subject's response, providing a comprehensive approach to TMS treatment with real-time feedback and visualization.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.