Quanterix has been granted a patent for methods and systems that enhance the dynamic range of assays for measuring analyte concentrations in fluid samples. The approach involves spatially segregating analytes, using capture objects, and employing detection methods to quantify analyte presence based on immobilized labeling agents. GlobalData’s report on Quanterix gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Quanterix, Laboratory automation robots was a key innovation area identified from patents. Quanterix's grant share as of July 2024 was 49%. Grant share is based on the ratio of number of grants to total number of patents.
Method for measuring analyte concentration in fluid samples
The patent US12019072B2 outlines a method for quantifying the concentration of analyte molecules or particles in a fluid sample. The process begins by exposing capture objects, which possess a binding surface with affinity for specific analytes, to a solution that may contain these analytes. Following this, binding ligands are associated with the analytes attached to the capture objects. A precursor labeling agent is then introduced, which is converted into a labeling agent that becomes immobilized near the capture objects. The method includes addressing the capture objects to detect the presence of the immobilized labeling agent, ultimately allowing for the determination of the analyte concentration based on the number of capture objects that exhibit this immobilization.
Further claims detail enhancements to the method, such as spatial segregation of capture objects into separate locations, which can be reaction vessels or regions on a planar surface. The patent specifies that these locations can contain single capture objects and that the labeling agent may be a precipitating agent. Additionally, the binding ligands may include enzymatic components, and the precursor labeling agent can be a nucleic acid, which is converted through amplification techniques. The method is applicable to fluid samples sourced from various biological entities, and it incorporates statistical analysis, such as Poisson distribution, to refine the concentration measurements based on the observed associations of the capture objects with the labeling agent.
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