Standard BioTools. has been granted a patent for methods that enable the incorporation of adaptors and nucleotide tags into target nucleic acids, facilitating high-throughput DNA sequencing. The patented methods also allow for the detection and quantification of different target nucleic acids using allele-specific tags in a single reaction mixture. GlobalData’s report on Standard BioTools gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Standard BioTools, Microfluidic devices was a key innovation area identified from patents. Standard BioTools's grant share as of June 2024 was 42%. Grant share is based on the ratio of number of grants to total number of patents.
Methods for detecting and quantifying target nucleic acids
The patent US12018323B2 outlines a method for detecting and quantifying multiple target nucleic acids within a single nucleic acid sample. This innovative approach involves conducting reactions in a single mixture to generate tagged target nucleotide sequences from at least two different target nucleic acids. Each sequence is tagged with distinct, allele-specific nucleotide tags, allowing for the differentiation of the target nucleic acids. The method includes performing primer extension reactions for each tagged sequence, where the presence and relative amounts of the target nucleic acids are determined by detecting signals indicative of primer extension. The patent also describes various amplification techniques, such as emulsion PCR and bridge PCR, to enhance the detection process.
Additionally, the claims detail the use of sequencing-by-synthesis techniques and oligonucleotide ligation for signal detection, with the potential for simultaneous or sequential reactions. The method is versatile, applicable to various target nucleic acids, including different alleles, altered copy numbers, and those located on the same or different chromosomes. The ability to produce and analyze three or more tagged sequences further expands the method's utility in complex nucleic acid samples. Overall, this patent presents a comprehensive framework for the efficient detection and quantification of multiple nucleic acids, which could have significant implications in genetic research and diagnostics.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
