Talis Biomedical has been granted a patent for a magnetic mixing apparatus designed to mix fluid samples with minimal contact between a stir bar and the chamber walls. The method includes cell lysis through pneumatic pressure and magnetic coupling, facilitating efficient sample processing. GlobalData’s report on Talis Biomedical gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Talis Biomedical, Microfluidics automation was a key innovation area identified from patents. Talis Biomedical's grant share as of June 2024 was 26%. Grant share is based on the ratio of number of grants to total number of patents.
Magnetic mixing apparatus for fluid sample lysis
The granted patent US11998883B2 outlines a method for lysing cells within a fluid sample using a specialized mixing assembly. The process begins with loading the fluid sample into a sample loading well, followed by the application of pneumatic pressure to transfer the sample into a mixing chamber. A driving magnet system is then energized to rotate a driven magnet, which is magnetically coupled to the drive magnet. This rotation facilitates the mixing of the fluid sample via a stir bar, also magnetically coupled, ultimately producing a lysed sample. The method includes steps for stopping the stir bar's rotation and advancing the lysed sample through a filter channel to a sample exit channel. Additional claims detail the incorporation of a lysis buffer and various chemical lysing agents, as well as the use of pneumatic pressure during the lysis process.
Further claims specify operational parameters, such as the dimensions of the mixing chamber and the gap between the driving and driven magnetic systems, which range from 10 mm to 30 mm and 1 mm to 200 mm, respectively. The mixing chamber can hold volumes between 0.1 mL to 100 mL, with the stir bar volume ranging from 50 µL to 10 mL. The patent also describes methods for detecting the decoupling of the stir bar from the magnetic systems, utilizing devices like microphones or accelerometers to ensure effective operation. Overall, the patent presents a comprehensive approach to cell lysis and mixing, emphasizing the integration of pneumatic pressure and magnetic coupling in the process.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
