Terumo has been granted a patent for a sensor designed to detect analyte concentrations, including potassium, oxygen, carbon dioxide, and hydrogen ions. The sensor utilizes a matrix material, nanoparticles, and specific signaling molecules that exhibit fluorescence intensity changes based on analyte levels. GlobalData’s report on Terumo gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Terumo, Prosthetic cardiac valves was a key innovation area identified from patents. Terumo's grant share as of June 2024 was 46%. Grant share is based on the ratio of number of grants to total number of patents.

Fluorescent sensor for detecting analyte concentrations

Source: United States Patent and Trademark Office (USPTO). Credit: Terumo Corp

The patent US12042281B2 describes a novel sensor designed for the detection of specific analytes, including potassium, oxygen, carbon dioxide, and hydrogen ions. The sensor comprises a matrix material, a nanoparticle associated with this matrix, and a plurality of signaling molecules, which include hydroxypyrenetrisulfonic acid (HPTS), benzo[ghi]perylene, and a coumarocryptand. Each signaling molecule is configured to respond to a single excitation wavelength, resulting in distinct fluorescence emission intensities that correlate with the concentration of the respective analytes. The sensor can utilize various types of nanoparticles, such as polymeric nanoparticles or quantum dots, and is designed to be optically coupled to a measuring device for enhanced detection capabilities.

Additionally, the patent outlines a method for detecting analyte concentrations in a fluid, which involves exposing the sensor to the fluid and the same excitation wavelength, followed by measuring the independent fluorescence emission intensities. The method is particularly applicable to biological fluids, such as blood, allowing for real-time monitoring of critical analyte levels. The sensor's design enables it to function as a ratiometric sensor, providing reliable and precise measurements of the targeted analytes, which is essential for various applications in medical diagnostics and environmental monitoring.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.