Venus Medtech Hangzhou. has been granted a patent for a method to prepare a pre-loadable dried biological heart valve. The process involves soaking fresh animal pericardium in a solution of soluble elastin or glycosaminoglycan, followed by two cross-linking reactions, resulting in a valve with enhanced toughness and rapid flattening capabilities. GlobalData’s report on Venus Medtech Hangzhou gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Venus Medtech Hangzhou, Prosthetic cardiac valves was a key innovation area identified from patents. Venus Medtech Hangzhou's grant share as of July 2024 was 47%. Grant share is based on the ratio of number of grants to total number of patents.
The patent US12064531B2 outlines a method for preparing a pre-loadable dried biological heart valve using fresh animal pericardium. The process involves two main steps: the first step entails soaking the pericardium in an aqueous solution containing soluble elastin or glycosaminoglycan, followed by a first cross-linking reaction using carbodiimide or N-hydroxysuccinimide. This step allows the soluble components to chemically bond with the pericardium. The second step involves a further cross-linking reaction with an aqueous glutaraldehyde solution, after which the pericardium is dried to yield the final dried biological heart valve. The method specifies conditions such as soaking times, concentrations, and temperatures to optimize the binding and cross-linking processes.
Additional claims detail specific parameters for each step, including the duration and concentration of the soaking solutions, as well as the drying process, which may involve gradient concentrations of alcohol solvents like isopropanol or glycerol. The patent also mentions a preliminary washing step for the pericardium, which can include treatments to remove cells, ensuring the integrity and suitability of the biological material for valve preparation. The resulting product is a pre-loadable dried biological heart valve, which is intended for use in medical applications, potentially improving the performance and longevity of heart valve replacements.
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