Veracyte. has filed a patent for methods, systems, and kits to identify homologous recombination deficiency prostate cancer in a subject. The patent includes biomarkers, genomic classifiers, and bioinformatic methods for diagnosis and prognosis. It also covers predicting response to anticancer therapy based on expression analysis. GlobalData’s report on Veracyte gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Veracyte, ML-based biomarker screening was a key innovation area identified from patents. Veracyte's grant share as of January 2024 was 26%. Grant share is based on the ratio of number of grants to total number of patents.
Diagnosis and treatment of homologous recombination deficiency prostate cancer
A patent application (Publication Number: US20240002944A1) outlines a method for diagnosing and treating prostate cancer based on the expression levels of specific nucleic acid targets. The method involves obtaining a biological sample from a subject with prostate cancer, detecting the expression levels of targets listed in Table 6 or Table 7, and prognosing the patient with homologous recombination deficiency prostate cancer. If the patient is determined to have this type of cancer, treatment with a PARP inhibitor is recommended. Additionally, the method includes administering alternative anti-cancer treatments if the expression levels indicate the absence of homologous recombination deficiency prostate cancer, such as surgery, chemotherapy, or immunotherapy.
Furthermore, the patent application describes a kit for identifying, diagnosing, and prognosing prostate cancer in a subject. The kit includes agents for detecting the presence or expression levels of specific targets, reagents for various detection methods like in situ hybridization or PCR-based methods, and probes capable of hybridizing to target nucleic acids. The kit also provides information on determining the subject's responsiveness to anti-cancer therapy and includes control reference samples for accuracy. Additionally, a probe set and system for analyzing prostate cancer are detailed, incorporating a computer model for determining the presence of homologous recombination deficiency prostate cancer based on nucleic acid expression levels. Overall, the patent application offers a comprehensive approach to diagnosing and treating prostate cancer based on specific gene expression patterns.
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