The latest RNAscope HiPlex12 Flex Kit enables researchers to visualise multiplexed RNA biomarkers using the Hyperion XTi. Credit: CDC on Unsplash.

Bio-Techne has launched a new RNAscope multiomic workflow for the Standard BioTools Hyperion Imaging System.

The new workflow expands the company’s Advanced Cell Diagnostics-branded RNAscope in situ hybridisation portfolio.

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The latest RNAscope HiPlex12 Flex Kit allows researchers to visualise multiplexed RNA biomarkers using the Hyperion XTi or previous models of the Hyperion Imaging System.

Using Imaging Mass Cytometry, the advanced system will enable researchers to simultaneously detect and precisely quantify more than 40 biomarkers in any tissue sample in a single imaging step.

Standard BioTools president and CEO Dr Michael Egholm said: “We are thrilled that Imaging Mass Cytometry, with the fastest sample-to-answer workflow available for high-plex imaging, now can complement its leading protein-mapping capability with RNA to significantly expand the menu of the targets that can be visualized in a single scan.”

The new multiomic workflow offers a convenient approach for incorporating prelabelled and user-conjugated Maxpar Antibodies from Standard BioTools during the sample preparation process.

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It empowers researchers to illuminate variations in cell phenotypes and functionality across a diverse spectrum of diseases by utilising conventional formalin-fixed paraffin-embedded tissue pathology slides.

Bio-Techne’s diagnostics and genomics segment president Kim Kelderman said: “Empowering the research community with best-in-class multiomic spatial imaging solutions using RNAscope technology is central to our long-term growth strategy.

“We are excited to expand the utility of RNAscope to include Imaging Mass Cytometry to enable more researchers to uncover new multiomic insights and advance the development of next-generation therapeutics and diagnostics.”

Last month, Bio-Techne reached a strategic partnership with Lunaphore to develop a fully automated spatial multiomics solution for same-slide hyperplex detection of protein and RNA biomarkers.