The test involves patients giving a blood sample, which is used to extract DNA for limited sequencing. Credit Nguyễn Hiệp on Unsplash.

Researchers from the Wellcome-MRC Cambridge Stem Cell Institute (CSCI), the University of Cambridge’s Department of Haematology and the Instituto de Investigación Sanitaria del Principado de Asturias (ISPA) have developed a new test to detect individuals at risk of developing different myeloid leukaemias.

Named MN-predict, the new platform will enable doctors and scientists to detect individuals at risk early and design new treatments for preventing the development of these potentially deadly cancers.

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Researchers have analysed data from over 400,000 participants in the United Kingdom Biobank.

Utilising this data, they have developed a new platform to forecast the likelihood of developing blood cancers, such as myelodysplastic syndromes, myeloproliferative neoplasms and myeloid leukaemia, over a period of 10-15 years.

Currently offered at NHS clinics, the test involves patients giving a blood sample, which is used to extract DNA for limited sequencing, along with basic blood cell counts.

With this information, MN-predict can identify individuals with a high risk of developing any of these cancers. It can be deployed within specialist clinics focused on leukaemia prevention.

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The study’s senior author, Professor George Vassiliou, said: “We all know that prevention is better than cure, but it is not easy to prevent diseases like leukaemia without knowing who is at risk.

“MN-predict makes it possible to identify at-risk individuals and we hope it can become an essential part of future leukaemia prevention programmes.”